Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate
Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19988/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050850/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.1749 |
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