Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase ι

Human DNA polymerase ι (polι) is a Y-family polymerase whose cellular function is presently unknown. Here, we report on the ability of polι to bypass various stereoisomers of benzo[a]pyrene (BaP) diol epoxide (DE) and benzo[c]phenanthrene (BcPh) DE adducts at deoxyadenosine (dA) or deoxyguanosine (d...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Frank, Ekaterina G., Sayer, Jane M., Kroth, Heiko, Ohashi, Eiji, Ohmori, Haruo, Jerina, Donald M., Woodgate, Roger
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2002
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137958/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12466554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf643
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