Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents

DNA topoisomerase II (Top2) is the target of some of the most effective anticancer DNA intercalators. To determine the effect of intercalating ligands at defined positions relative to a known DNA cleavage site for human Top2α, we synthesized oligodeoxynucleotides containing single trans-opened benzo...

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Hlavní autoři: Khan, Qasim A., Kohlhagen, Glenda, Marshall, Richard, Austin, Caroline A., Kalena, Govind P., Kroth, Heiko, Sayer, Jane M., Jerina, Donald M., Pommier, Yves
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC218786/
https://ncbi.nlm.nih.gov/pubmed/14523238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2032456100
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