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Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents

DNA topoisomerase II (Top2) is the target of some of the most effective anticancer DNA intercalators. To determine the effect of intercalating ligands at defined positions relative to a known DNA cleavage site for human Top2α, we synthesized oligodeoxynucleotides containing single trans-opened benzo...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Khan, Qasim A., Kohlhagen, Glenda, Marshall, Richard, Austin, Caroline A., Kalena, Govind P., Kroth, Heiko, Sayer, Jane M., Jerina, Donald M., Pommier, Yves
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2003
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC218786/
https://ncbi.nlm.nih.gov/pubmed/14523238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2032456100
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