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Nucleotide incorporation by human DNA polymerase γ opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine
Mitochondria are major cellular targets of benzo[a]pyrene (BaP), a known carcinogen that also inhibits mitochondrial proliferation. Here, we report for the first time the effect of site-specific N(2)-deoxyguanosine (dG) and N(6)-deoxyadenosine (dA) adducts derived from BaP 7,8-diol 9,10-epoxide (BaP...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373300/ https://ncbi.nlm.nih.gov/pubmed/14729924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh213 |
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