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Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N(2)-deoxyguanosine adduct: Absolute configuration and conformation

Benzo[a]pyrene 7,8-diol 9,10-epoxide adducts in DNA are implicated in mutagenesis, and their formation from the diol epoxides and subsequent incorrect replication by human DNA polymerases provide an attractive mechanism for the induction of cancer by this highly carcinogenic hydrocarbon and its diol...

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Main Authors: Karle, Isabella L., Yagi, Haruhiko, Sayer, Jane M., Jerina, Donald M.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC341736/
https://ncbi.nlm.nih.gov/pubmed/14757823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307305101
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