Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N(2)-deoxyguanosine adduct: Absolute configuration and conformation
Benzo[a]pyrene 7,8-diol 9,10-epoxide adducts in DNA are implicated in mutagenesis, and their formation from the diol epoxides and subsequent incorrect replication by human DNA polymerases provide an attractive mechanism for the induction of cancer by this highly carcinogenic hydrocarbon and its diol...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341736/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14757823/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307305101 |
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