Position-specific trapping of topoisomerase I–DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine

DNA topoisomerase I (top1) is the target of potent anticancer agents, including camptothecins and DNA intercalators, which reversibly stabilize (trap) top1 catalytic intermediates (cleavage complexes). The aim of the present study was to define the structural relationship between the site(s) of cova...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Pommier, Yves, Laco, Gary S., Kohlhagen, Glenda, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2000
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27093/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190312697
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