Position-specific trapping of topoisomerase I–DNA cleavage complexes by intercalated benzo[a]- pyrene diol epoxide adducts at the 6-amino group of adenine

DNA topoisomerase I (top1) is the target of potent anticancer agents, including camptothecins and DNA intercalators, which reversibly stabilize (trap) top1 catalytic intermediates (cleavage complexes). The aim of the present study was to define the structural relationship between the site(s) of cova...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Pommier, Yves, Laco, Gary S., Kohlhagen, Glenda, Sayer, Jane M., Kroth, Heiko, Jerina, Donald M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27093/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190312697
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