Yüklüyor......

Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

Checkpoint kinase 2 (Chk2), a ser/thr kinase involved in the ATM-Chk2 checkpoint pathway, is activated by genomic instability and DNA damage and results in either arrest of the cell cycle to allow DNA repair to occur or apoptosis if the DNA damage is severe. Drugs that specifically target Chk2 could...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Lountos, George T, Tropea, Joseph E, Zhang, Di, Jobson, Andrew G, Pommier, Yves, Shoemaker, Robert H, Waugh, David S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley Subscription Services, Inc., A Wiley Company 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708046/
https://ncbi.nlm.nih.gov/pubmed/19177354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.16
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!