X-ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket

The serine/threonine checkpoint kinase 2 (Chk2) is an attractive molecular target for the development of small molecule inhibitors to treat cancer. Here, we report the rational design of Chk2 inhibitors that target the gatekeeper-dependent hydrophobic pocket located behind the adenine-binding region...

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Detalhes bibliográficos
Main Authors: Lountos, George T., Jobson, Andrew G., Tropea, Joseph E., Self, Christopher R., Zhang, Guangtao, Pommier, Yves, Shoemaker, Robert H., Waugh, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195894/
https://ncbi.nlm.nih.gov/pubmed/21907711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.08.050
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