Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated pathway, which is activated by genomic instability and DNA damage, leading to either cell death (apoptosis) or cell cycle arrest. Chk2 provides an unexplored therapeutic target against cancer cells. We recently reported 4,4′-d...

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Autores principales: Jobson, Andrew G., Lountos, George T., Lorenzi, Philip L., Llamas, Jenny, Connelly, John, Cerna, David, Tropea, Joseph E., Onda, Akikazu, Zoppoli, Gabriele, Kondapaka, Sudhir, Zhang, Guangtao, Caplen, Natasha J., Cardellina, John H., Yoo, Stephen S., Monks, Anne, Self, Christopher, Waugh, David S., Shoemaker, Robert H., Pommier, Yves
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2009
Materias:
Cellular and Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784710/
https://ncbi.nlm.nih.gov/pubmed/19741151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.154997
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