Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy

Chk2 (checkpoint kinase 2) is a serine/threonine kinase that participates in a series of signaling networks responsible for maintaining genomic integrity and responding to DNA damage. The development of selective Chk2 inhibitors has recently attracted much interest as a means of sensitizing cancer c...

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Detalhes bibliográficos
Main Authors: Lountos, George T., Jobson, Andrew G., Tropea, Joseph E., Self, Christopher R., Zhang, Guangtao, Pommier, Yves, Shoemaker, Robert H., Waugh, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210331/
https://ncbi.nlm.nih.gov/pubmed/21963792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2011.09.008
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