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Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor
Checkpoint kinase 2 (Chk2), a ser/thr kinase involved in the ATM-Chk2 checkpoint pathway, is activated by genomic instability and DNA damage and results in either arrest of the cell cycle to allow DNA repair to occur or apoptosis if the DNA damage is severe. Drugs that specifically target Chk2 could...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708046/ https://ncbi.nlm.nih.gov/pubmed/19177354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.16 |
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