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Crystal structure of the human dual specificity phosphatase 1 catalytic domain

The dual specificity phosphatase DUSP1 was the first mitogen activated protein kinase phosphatase (MKP) to be identified. It dephosphorylates conserved tyrosine and threonine residues in the activation loops of mitogen activated protein kinases ERK2, JNK1 and p38‐alpha. Here, we report the crystal s...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Gumpena, Rajesh, Lountos, George T., Raran‐Kurussi, Sreejith, Tropea, Joseph E., Cherry, Scott, Waugh, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775162/
https://ncbi.nlm.nih.gov/pubmed/29052270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3328
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