Crystal structure of the human dual specificity phosphatase 1 catalytic domain

The dual specificity phosphatase DUSP1 was the first mitogen activated protein kinase phosphatase (MKP) to be identified. It dephosphorylates conserved tyrosine and threonine residues in the activation loops of mitogen activated protein kinases ERK2, JNK1 and p38‐alpha. Here, we report the crystal s...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Gumpena, Rajesh, Lountos, George T., Raran‐Kurussi, Sreejith, Tropea, Joseph E., Cherry, Scott, Waugh, David S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Protein Structure Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775162/
https://ncbi.nlm.nih.gov/pubmed/29052270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3328
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