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Third-Generation Immucillins: Syntheses and Bio-Activities of Acyclic Immucillin Inhibitors of Human Purine Nucleoside Phosphorylase
ImmH (1) and DADMe-ImmH (2) are potent inhibitors of human purine nucleoside phoshorylase (PNP), developed by us and currently in clinical trials for the treatment of a variety of T-cell related diseases. Compounds 1 and 2 were used as templates for the design and synthesis of a series of acyclic im...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698043/ https://ncbi.nlm.nih.gov/pubmed/19170524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801421q |
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