Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes

Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase (PNP). In humans, PNP is the only route for degradation of deoxyguanosine, and genetic deficiency of this enzyme leads to profound T cell-mediated immunosuppression. This s...

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Bibliografiske detaljer
Main Authors: Kicska, Greg A., Long, Li, Hörig, Heidi, Fairchild, Craig, Tyler, Peter C., Furneaux, Richard H., Schramm, Vern L., Kaufman, Howard L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC31879/
https://ncbi.nlm.nih.gov/pubmed/11287638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.071050798
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