Third-Generation Immucillins: Syntheses and Bio-Activities of Acyclic Immucillin Inhibitors of Human Purine Nucleoside Phosphorylase

ImmH (1) and DADMe-ImmH (2) are potent inhibitors of human purine nucleoside phoshorylase (PNP), developed by us and currently in clinical trials for the treatment of a variety of T-cell related diseases. Compounds 1 and 2 were used as templates for the design and synthesis of a series of acyclic im...

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Main Authors: Clinch, Keith, Evans, Gary B., Fröhlich, Richard F.G., Furneaux, Richard H., Kelly, Peter M., Legentil, Laurent, Murkin, Andrew S., Li, Lei, Schramm, Vern L., Tyler, Peter C., Woolhouse, Anthony D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698043/
https://ncbi.nlm.nih.gov/pubmed/19170524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801421q
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