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Many different Vβ CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions
We have hypothesized that in the prenegative selection TCR repertoire, many somatically generated complementary-determining region (CDR) 3 loops combine with evolutionarily selected germline Vα/Vβ CDR1/CDR2 loops to create highly MHC/peptide cross-reactive T cells that are subsequently deleted by ne...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674405/ https://ncbi.nlm.nih.gov/pubmed/19416894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902728106 |
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