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Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules

The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility complex molecules presenting peptide antigens (pMHC). It remains unclear whether germline TCR sequenc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Krovi, S. Harsha, Kappler, John W., Marrack, Philippa, Gapin, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825295/
https://ncbi.nlm.nih.gov/pubmed/31570608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909504116
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