Alternate interactions define the binding of peptides to the MHC molecule IA(b)

We have solved the crystal structure of the MHCII molecule, IA(b), containing an antigenic variant of the major IA(b)-binding peptide derived from the MHCII IEα chain. The four MHC pockets at p1, p4, p6, and p9 that usually bind peptide side chains are largely empty because of alanines in the peptid...

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Main Authors: Liu, Xinqi, Dai, Shaodong, Crawford, Frances, Frugé, Rachel, Marrack, Philippa, Kappler, John
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2002
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC124382/
https://ncbi.nlm.nih.gov/pubmed/12084926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132272099
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