Alternate interactions define the binding of peptides to the MHC molecule IA(b)

We have solved the crystal structure of the MHCII molecule, IA(b), containing an antigenic variant of the major IA(b)-binding peptide derived from the MHCII IEα chain. The four MHC pockets at p1, p4, p6, and p9 that usually bind peptide side chains are largely empty because of alanines in the peptid...

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Detalles Bibliográficos
Main Authors: Liu, Xinqi, Dai, Shaodong, Crawford, Frances, Frugé, Rachel, Marrack, Philippa, Kappler, John
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC124382/
https://ncbi.nlm.nih.gov/pubmed/12084926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132272099
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