Alternate interactions define the binding of peptides to the MHC molecule IA(b)

We have solved the crystal structure of the MHCII molecule, IA(b), containing an antigenic variant of the major IA(b)-binding peptide derived from the MHCII IEα chain. The four MHC pockets at p1, p4, p6, and p9 that usually bind peptide side chains are largely empty because of alanines in the peptid...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Liu, Xinqi, Dai, Shaodong, Crawford, Frances, Frugé, Rachel, Marrack, Philippa, Kappler, John
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2002
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC124382/
https://ncbi.nlm.nih.gov/pubmed/12084926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132272099
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