Alternate interactions define the binding of peptides to the MHC molecule IA(b)

We have solved the crystal structure of the MHCII molecule, IA(b), containing an antigenic variant of the major IA(b)-binding peptide derived from the MHCII IEα chain. The four MHC pockets at p1, p4, p6, and p9 that usually bind peptide side chains are largely empty because of alanines in the peptid...

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Bibliografiske detaljer
Main Authors: Liu, Xinqi, Dai, Shaodong, Crawford, Frances, Frugé, Rachel, Marrack, Philippa, Kappler, John
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124382/
https://ncbi.nlm.nih.gov/pubmed/12084926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132272099
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