טוען...
Many different Vβ CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions
We have hypothesized that in the prenegative selection TCR repertoire, many somatically generated complementary-determining region (CDR) 3 loops combine with evolutionarily selected germline Vα/Vβ CDR1/CDR2 loops to create highly MHC/peptide cross-reactive T cells that are subsequently deleted by ne...
שמור ב:
| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2009
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674405/ https://ncbi.nlm.nih.gov/pubmed/19416894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902728106 |
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