A single T cell receptor bound to major histocompatibility complex class I and class II glycoproteins reveals switchable TCR conformers

Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and sequence. To understand how T cell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presented the first comparison of a single TCR bound to both MHCI and MHCII ligands....

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Main Authors: Yin, Lei, Huseby, Eric, Scott-Browne, James, Rubtsova, Kira, Pinilla, Clamencia, Crawford, Frances, Marrack, Philippa, Dai, Shaodong, Kappler, John W.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160269/
https://ncbi.nlm.nih.gov/pubmed/21683626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.017
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