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Crossreactive T cells spotlight the germline rules for αβ T cell receptor interactions with MHC molecules
We have suggested that highly crossreactive αβ T cell receptors (TCRs) obtained by limited negative selection will best illustrate germline-encoded TCR-MHC interactions. To test this, we solved the structures of 3 TCRs bound to the same MHCII/peptide (IA(b)/3K). The TCRs had similar affinities for I...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2287197/ https://ncbi.nlm.nih.gov/pubmed/18308592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.01.008 |
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