Crossreactive T cells spotlight the germline rules for αβ T cell receptor interactions with MHC molecules

We have suggested that highly crossreactive αβ T cell receptors (TCRs) obtained by limited negative selection will best illustrate germline-encoded TCR-MHC interactions. To test this, we solved the structures of 3 TCRs bound to the same MHCII/peptide (IA(b)/3K). The TCRs had similar affinities for I...

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Main Authors: Dai, Shaodong, Huseby, Eric S., Rubtsova, Kira, Scott-Browne, James, Crawford, Frances, Macdonald, Whitney A., Kappler, John W., Marrack, Philippa
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2287197/
https://ncbi.nlm.nih.gov/pubmed/18308592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.01.008
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