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Germline-encoded amino acids in the αβ T cell receptor control thymic selection

An αβ T cell response depends on the recognition of antigen plus major histocompatibility complex proteins (MHC)1 by its antigen receptor (TCR). The ability of peripheral αβ T cells to recognize MHC is at least partly determined by MHC dependent thymic selection, by which an immature T cell survives...

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Detalhes bibliográficos
Main Authors: Scott-Browne, James P., White, Janice, Kappler, John W., Gapin, Laurent, Marrack, Philippa
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679808/
https://ncbi.nlm.nih.gov/pubmed/19262510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07812
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