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Evolutionarily conserved amino acids in TCR V regions and MHC control their interaction
Alpha/beta T cell receptors (TCRs) react with major histocompatibility complex proteins (MHC) plus peptides, a poorly understood phenomenon, probably because thymocytes bearing TCRs that manifest MHC-reactivity too well are lost by negative selection. Only TCRs with attenuated ability to react with...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164820/ https://ncbi.nlm.nih.gov/pubmed/18304006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev.immunol.26.021607.090421 |
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