Intrathecal Raf-1-selective siRNA attenuates sustained morphinemediated thermal hyperalgesia

Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced...

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Hlavní autoři: Tumati, Suneeta, Milnes, Tally Largent, Yamamura, Henry I., Vanderah, Todd W., Roeske, William R., Varga, Eva V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640499/
https://ncbi.nlm.nih.gov/pubmed/18976650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.10.033
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