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Intrathecal Raf-1-selective siRNA attenuates sustained morphinemediated thermal hyperalgesia

Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced...

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Библиографические подробности
Главные авторы: Tumati, Suneeta, Milnes, Tally Largent, Yamamura, Henry I., Vanderah, Todd W., Roeske, William R., Varga, Eva V.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640499/
https://ncbi.nlm.nih.gov/pubmed/18976650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.10.033
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