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Intrathecal Raf-1-selective siRNA attenuates sustained morphinemediated thermal hyperalgesia
Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2640499/ https://ncbi.nlm.nih.gov/pubmed/18976650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.10.033 |
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