Sustained Morphine Treatment Augments Capsaicin-Evoked Calcitonin Gene-Related Peptide Release from Primary Sensory Neurons in a Protein Kinase A- and Raf-1-Dependent Manner

Studies have shown that long-term (5α,6α)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-mediated pain sensitization are not fully understoo...

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Hlavní autoři: Tumati, Suneeta, Yamamura, Henry I., Vanderah, Todd W., Roeske, William R., Varga, Eva V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Neuropharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729797/
https://ncbi.nlm.nih.gov/pubmed/19491327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.151704
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