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Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist

Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization. Since activation of glial CB2 cannabinoid receptors attenuates spinal glial activation in neuropathies, we hypothesized that CB2 agonists may also attenuate sustained morphine–mediated spinal g...

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Detalhes bibliográficos
Main Authors: Tumati, Suneeta, Largent-Milnes, Tally M, Keresztes, Attila, Ren, Jiyang, Roeske, William R, Vanderah, Todd W., Varga, Eva V
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298577/
https://ncbi.nlm.nih.gov/pubmed/22285397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2011.12.021
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