Tachykinin NK(1) receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

Prolonged morphine treatment increases pain sensitivity in many patients. Enhanced spinal Substance P release is one of the adaptive changes associated with sustained opioid exposure. In addition to pain transmitting second order neurons, spinal microglia and astrocytes also express functionally act...

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Autori principali: Tumati, Suneeta, Largent-Milnes, Tally M., Keresztes, Attila I., Yamamoto, Takashi, Vanderah, Todd W., Roeske, William R., Hruby, Victor J., Varga, Eva V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565540/
https://ncbi.nlm.nih.gov/pubmed/22724132
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