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Intrathecal Raf-1-selective siRNA attenuates sustained morphinemediated thermal hyperalgesia
Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2640499/ https://ncbi.nlm.nih.gov/pubmed/18976650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.10.033 |
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