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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what appears to be premature aging, is caused by the production of a mutant form of prelamin A known as progerin. Progerin retains a farnesyl lipid anchor at its carboxyl terminus, a modification that is thought to be import...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525700/ https://ncbi.nlm.nih.gov/pubmed/18769635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35876 |
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