Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

Samankaltaisia teoksia

• Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin
  Tekijä: Yang, Shao H., et al.
  Julkaistu: (2011)
• Increasing the length of progerin’s isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome
  Tekijä: Davies, Brandon S. J., et al.
  Julkaistu: (2009)
• An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
  Tekijä: Davies, Brandon S.J., et al.
  Julkaistu: (2010)
• Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides
  Tekijä: Fong, Loren G., et al.
  Julkaistu: (2009)
• Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
  Tekijä: Yang, Shao H., et al.
  Julkaistu: (2010)