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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what appears to be premature aging, is caused by the production of a mutant form of prelamin A known as progerin. Progerin retains a farnesyl lipid anchor at its carboxyl terminus, a modification that is thought to be import...

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Autors principals: Yang, Shao H., Andres, Douglas A., Spielmann, H. Peter, Young, Stephen G., Fong, Loren G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525700/
https://ncbi.nlm.nih.gov/pubmed/18769635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35876
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