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Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β(2)-Adrenergic Receptor
Agonist-stimulated β(2)-adrenergic receptor (β(2)AR) ubiquitination is a major factor that governs both lysosomal trafficking and degradation of internalized receptors, but the identity of the E3 ubiquitin ligase regulating this process was unknown. Among the various catalytically inactive E3 ubiqui...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2494938/ https://ncbi.nlm.nih.gov/pubmed/18544533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709668200 |
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