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β(2)-Adrenergic Receptor Lysosomal Trafficking Is Regulated by Ubiquitination of Lysyl Residues in Two Distinct Receptor Domains

Agonist stimulation of the β(2)-adrenergic receptors (β(2)ARs) leads to their ubiquitination and lysosomal degradation. Inhibition of lysosomal proteases results in the stabilization and retention of internalized full-length β(2)ARs in the lysosomes, whereas inhibition of proteasomal proteases stabi...

詳細記述

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書誌詳細
主要な著者: Xiao, Kunhong, Shenoy, Sudha K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069478/
https://ncbi.nlm.nih.gov/pubmed/21330366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.203091
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