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β(2)-Adrenergic Receptor Lysosomal Trafficking Is Regulated by Ubiquitination of Lysyl Residues in Two Distinct Receptor Domains
Agonist stimulation of the β(2)-adrenergic receptors (β(2)ARs) leads to their ubiquitination and lysosomal degradation. Inhibition of lysosomal proteases results in the stabilization and retention of internalized full-length β(2)ARs in the lysosomes, whereas inhibition of proteasomal proteases stabi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069478/ https://ncbi.nlm.nih.gov/pubmed/21330366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.203091 |
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