The deubiquitinase ubiquitin–specific protease 20 is a positive modulator of myocardial β(1)-adrenergic receptor expression and signaling

Reversible ubiquitination of G protein–coupled receptors regulates their trafficking and signaling; whether deubiquitinases regulate myocardial β(1)-adrenergic receptors (β(1)ARs) is unknown. We report that ubiquitin-specific protease 20 (USP20) deubiquitinates and attenuates lysosomal trafficking o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yu, Samuel Mon-Wei, Jean-Charles, Pierre-Yves, Abraham, Dennis M., Kaur, Suneet, Gareri, Clarice, Mao, Lan, Rockman, Howard A., Shenoy, Sudha K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378982/
https://ncbi.nlm.nih.gov/pubmed/30538132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004926
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