Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation

Toll-like receptor 4 (TLR4) promotes vascular inflammatory disorders such as neointimal hyperplasia and atherosclerosis. TLR4 triggers NFκB signaling through the ubiquitin ligase TRAF6 (tumor necrosis factor receptor-associated factor 6). TRAF6 activity can be impeded by deubiquitinating enzymes lik...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Jean-Charles, Pierre-Yves, Zhang, Lisheng, Wu, Jiao-Hui, Han, Sang-oh, Brian, Leigh, Freedman, Neil J., Shenoy, Sudha K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817176/
https://ncbi.nlm.nih.gov/pubmed/26839314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.687129
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