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Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β(2)-Adrenergic Receptor
Agonist-stimulated β(2)-adrenergic receptor (β(2)AR) ubiquitination is a major factor that governs both lysosomal trafficking and degradation of internalized receptors, but the identity of the E3 ubiquitin ligase regulating this process was unknown. Among the various catalytically inactive E3 ubiqui...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2494938/ https://ncbi.nlm.nih.gov/pubmed/18544533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709668200 |
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