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Ubiquitin ligase Nedd4 promotes α-synuclein degradation by the endosomal–lysosomal pathway
α-Synuclein is an abundant brain protein that binds to lipid membranes and is involved in the recycling of presynaptic vesicles. In Parkinson disease, α-synuclein accumulates in intraneuronal inclusions often containing ubiquitin chains. Here we show that the ubiquitin ligase Nedd4, which functions...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193191/ https://ncbi.nlm.nih.gov/pubmed/21953697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109356108 |
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