Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

α-Synuclein (aS) is a major constituent of Lewy bodies, which are not only a pathological marker for Parkinson disease but also a trigger for neurodegeneration. Cumulative evidence suggests that aS spreads from cell to cell and thereby propagates neurodegeneration to neighboring cells. Recently, Ned...

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Main Authors: Sugeno, Naoto, Hasegawa, Takafumi, Tanaka, Nobuyuki, Fukuda, Mitsunori, Wakabayashi, Koichi, Oshima, Ryuji, Konno, Masashi, Miura, Emiko, Kikuchi, Akio, Baba, Toru, Anan, Tadashi, Nakao, Mitsuyoshi, Geisler, Sven, Aoki, Masashi, Takeda, Atsushi
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Neurobiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140275/
https://ncbi.nlm.nih.gov/pubmed/24831002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529461
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