S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains

Ubiquitin (Ub)–protein conjugates formed by purified ring-finger or U-box E3s with the E2, UbcH5, resist degradation and disassembly by 26S proteasomes. These chains contain multiple types of Ub forks in which two Ub's are linked to adjacent lysines on the proximal Ub. We tested whether cells c...

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Hlavní autoři: Kim, Hyoung Tae, Kim, Kwang Pyo, Uchiki, Tomoaki, Gygi, Steven P, Goldberg, Alfred L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711177/
https://ncbi.nlm.nih.gov/pubmed/19387488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.115
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