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Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?
Although cellular proteins conjugated to K48-linked Ub chains are targeted to proteasomes, proteins conjugated to K63-ubiquitin chains are directed to lysosomes. However, pure 26S proteasomes bind and degrade K48- and K63-ubiquitinated substrates similarly. Therefore, we investigated why K63-ubiquit...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3579138/ https://ncbi.nlm.nih.gov/pubmed/23314748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.354 |
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