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Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

Although cellular proteins conjugated to K48-linked Ub chains are targeted to proteasomes, proteins conjugated to K63-ubiquitin chains are directed to lysosomes. However, pure 26S proteasomes bind and degrade K48- and K63-ubiquitinated substrates similarly. Therefore, we investigated why K63-ubiquit...

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Bibliografske podrobnosti
Main Authors: Nathan, James A, Tae Kim, Hyoung, Ting, Lily, Gygi, Steven P, Goldberg, Alfred L
Format: Artigo
Jezik:Inglês
Izdano: European Molecular Biology Organization 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579138/
https://ncbi.nlm.nih.gov/pubmed/23314748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.354
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