The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains

Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 polyubiquitin chains. Whether the proteasome also can bind atypical ubiquitin chains, including those linked by lysine-11, has not been well established. This is critically important, as lysine-11 polyubiquitina...

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Pubblicato in:Cell Rep
Autori principali: Grice, Guinevere L., Lobb, Ian T., Weekes, Michael P., Gygi, Steven P., Antrobus, Robin, Nathan, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2015
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533228/
https://ncbi.nlm.nih.gov/pubmed/26190103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.061
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