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Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

Recruitment of substrates to the 26S proteasome usually requires covalent attachment of the Lys48-linked polyubiquitin chain. In contrast, modifications with the Lys63-linked polyubiquitin chain and/or monomeric ubiquitin are generally thought to function in proteasome-independent cellular processes...

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Autori principali: Saeki, Yasushi, Kudo, Tai, Sone, Takayuki, Kikuchi, Yoshiko, Yokosawa, Hideyoshi, Toh-e, Akio, Tanaka, Keiji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646160/
https://ncbi.nlm.nih.gov/pubmed/19153599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.305
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