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Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome
Recruitment of substrates to the 26S proteasome usually requires covalent attachment of the Lys48-linked polyubiquitin chain. In contrast, modifications with the Lys63-linked polyubiquitin chain and/or monomeric ubiquitin are generally thought to function in proteasome-independent cellular processes...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646160/ https://ncbi.nlm.nih.gov/pubmed/19153599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.305 |
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