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mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
Growth factors and nutrients enhance protein synthesis and suppress overall protein degradation by activating the protein kinase mammalian target of rapamycin (mTOR). Conversely, nutrient or serum deprivation inhibits mTOR and stimulates protein breakdown by inducing autophagy, which provides the st...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703015/ https://ncbi.nlm.nih.gov/pubmed/26669439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521919112 |
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