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mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

Growth factors and nutrients enhance protein synthesis and suppress overall protein degradation by activating the protein kinase mammalian target of rapamycin (mTOR). Conversely, nutrient or serum deprivation inhibits mTOR and stimulates protein breakdown by inducing autophagy, which provides the st...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Zhao, Jinghui, Zhai, Bo, Gygi, Steven P., Goldberg, Alfred Lewis
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703015/
https://ncbi.nlm.nih.gov/pubmed/26669439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521919112
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