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mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

Growth factors and nutrients enhance protein synthesis and suppress overall protein degradation by activating the protein kinase mammalian target of rapamycin (mTOR). Conversely, nutrient or serum deprivation inhibits mTOR and stimulates protein breakdown by inducing autophagy, which provides the st...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhao, Jinghui, Zhai, Bo, Gygi, Steven P., Goldberg, Alfred Lewis
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703015/
https://ncbi.nlm.nih.gov/pubmed/26669439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521919112
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