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mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

Growth factors and nutrients enhance protein synthesis and suppress overall protein degradation by activating the protein kinase mammalian target of rapamycin (mTOR). Conversely, nutrient or serum deprivation inhibits mTOR and stimulates protein breakdown by inducing autophagy, which provides the st...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhao, Jinghui, Zhai, Bo, Gygi, Steven P., Goldberg, Alfred Lewis
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703015/
https://ncbi.nlm.nih.gov/pubmed/26669439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521919112
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